Nose-only inhalation exposure system for small animals with multiple concentrations

The instrument is used to complete the Nose-only exposure of small animals, and is suitable for simultaneous inhalation exposure experiments of multiple concentration doses of gas and flue gas. For the first time in the world, the instrument realizes one aerosol generation from a single aerosol source and can simultaneously generate 3 to 5 concentration doses, thus ensuring the consistency of aerosol sources of different experimental groups and saving the usage of samples. In addition, users can also set different experimental doses on the instrument software, and the system can automatically detect and feedback and adjust to the target concentration.

01. In the field of drug safety evaluation

02.In the field of chemical and pesticide safety evaluation

03.The fields of inhalation immunization and environmental assessment

04.The field of respiratory disease modeling and efficacy evaluation

05.The field of radioactive material hazard assessment and protection

06.Military medicine and aerospace medicine

01.Can realize inhalation exposure test of homologous gas, vapor or mixture thereof in 3 gradients;

02.The special vortex mixing dilution technology ensures that the concentration of the inhaled test substance of each layer of animals is uniform and stable, and the concentration error is within ±8% of the average value;

03.Small floor space, low energy consumption and less sample consumption;

04.The maximum concentration gradient of 5 times can be realized.

05.Negative pressure protection system ensures the safety of test personnel;

1. Safety protection intelligent shielding cabinet　

The main structure is welded from high-quality steel and has excellent properties such as high temperature resistance, corrosion resistance, easy cleaning, etc. Ultra-large toughened transparent glass is used as the observation window, making animal observation barrier-free.

2. Oral and nasal exposure room

The exposure chamber can be freely combined and disassembled, and can meet various experimental requirements of different experimental animals (rats, mice, guinea pigs, etc.), different animal numbers (12, 24, 36, etc.), different exposure doses, etc. The exposure chamber can rotate freely, is flexible to operate, and is convenient to access animals; The exposure unit is small in volume, small in sample dosage, and convenient to connect with the glove box for strong toxicity experiments.

3. Sample generation and delivery system

(1) Liquid aerosol generator: used to generate liquid aerosol. The generated aerosol MMAD1-4μm and GSD1.5-3 meet OECD requirements. There are two types of aerosol generators with water as excipient and oil as excipient.

(2) Dust aerosol generator: used to generate dust aerosol. The generated aerosol MMAD1-4μm and GSD1.5-3 meet OECD requirements. There are two kinds of generators to choose from depending on the amount of sample.

(3) VOC gas quantitative generator: adopts glass ball pile countercurrent volatilization structure with high volatilization speed; The generated gas has controllable concentration and high continuous stability. The generating system is closed and has high safety. Volatilization rate: 0-5mL/min; Gas flow rate: 0-20L/min; Heating temperature: 20-60℃.

4. Environmental parameter monitoring system for exposure unit

The temperature, humidity, pressure difference, oxygen concentration and carbon dioxide concentration of the exposure chamber during the experiment can be detected.

5. Poison control system, host computer remote control system

The temperature, humidity, pressure difference, oxygen concentration and carbon dioxide concentration of the exposure chamber during the experiment can be detected.

6. Aerosol dilution and mixing system

It has excellent properties of high temperature resistance, corrosion resistance, easy cleaning and the like, and can rapidly and non-destructively mix the aerosol and stabilize the aerosol at the required concentration.

7. Aerosol Particle Size Distribution Analysis System (Optional)

The aerosol particle size spectrometer is used for analysis, and the particle size analysis range is 0.5-20μ m; Measuring flow: 5.0 L/min; Maximum particle concentration: 105P/cm3。

8. Aerosol mass concentration detection system

Consisting of CEL-712 mass concentration detector, it can observe the trend of aerosol particle mass concentration in real time and adjust it through control system. Measurement range: 0.001mg/m3 to 250 g/m3 (250,000 mg/m3); The storage capacity is large and can store 500 measurement results and 86000 data.

9. Gas control system

The gas control system consists of oil-free mute air compressor, filter, oil-free vacuum pump, flow controller and other parts, which can accurately control the gas flow of the exposed system.

10. Automatic sampling system

It consists of a sampler, a precision flow controller and a sampling pump, and automatically samples the aerosol in the exposure chamber.

11. Exhaust gas treatment system

Exhaust emissions fully meet national safety emission standards.

12. Anti-theft alarm system

The upper and lower limits of temperature, humidity, pressure difference, oxygen concentration, carbon dioxide concentration and other parameters can be set according to actual needs, and the computer can alarm abnormal conditions such as temperature anomaly, pressure difference anomaly and gas leakage according to the above settings.