Applicable to ABSL-3 and ABSL-4 laboratories, the system can perform inhalation exposure tests (e.g., inhalation poisoning, inhalation immunity, R&D of inhalation formulations) for 3 monkeys simultaneously. It consists of bioaerosol generator, monkey chair, Class III BSC cabinet, multifunctional exposure mask, exposure environment detector and controller, host controller, gas controller, bioaerosol sampler, aerosol mass concentration detector, bioaerosol waste gas treatment system and protection alarms. Aerosol exposure system complies with OECD inhalation guidelines. Aerosol is generated for animal inhalation, which realizes animal drug delivery with constant concentration and high efficiency via exposure mask, constant pressure recycling chamber, etc., and with recycling procedure for discarded samples. Equipped with control system and sensors, it can monitor, analyze and record data during tests, compliant with GLP requirements.
Perform inhalation exposure tests for 3 monkeys simultaneously.
Class III BSC cabinet: compact design in stainless steel, excellent corrosion resistance, large round corners design is easy to clean. Double-sided design allows multi-users to operate together.
Integrated safety design: integrated design of Class III BSC cabinet and exposure tower mainly includes safety program coordinated control, sterilization and purification program settings, corrosion-resistant sensors, double HEPA filtration, intelligent pressure difference control, internal and external interlock, startup self-test, etc.
Negative pressure inside cabinet is not less than 120Pa, and mask pressure is not less than 100Pa.
Exhaust HEPA filter is Class H14 with leakage detection and sterilization in place.
HMI has functions of parameter settings, real-time display and data recording, etc. Real-time monitor parameters of oxygen concentration, carbon dioxide concentration, temp, humidity, pressure (between cabinet and HEPA filter), and abnormal alarms.
One-to-one control of monkey mouth and nose inhalation, enhances dose stability, accuracy and reproducibility.
Translucent aerosol generator enables visual monitoring of liquid level and atomization. Liquid samples can be added midway without downtime.
Monkey chair fits 3-6kg monkeys with adjustable sitting angle which makes monkey feel better.
The seat and back of the monkey chair are made of PTFE for comfort. A removable waste collector is located underneath the seat panel.
Monkeys can be quickly bound by velcro tape, which is convenient and reliable.
Class III BSC cabinet dimensions is less than 3100*900*2250mm with working area 1794*835*900mm.
Monkey chair angle can be adjusted ±90°.
Extraction flow and sampling flow are both 1-30L/min (adjustable).
Monkey chair size 340*300*600 mm.
Negative pressure inside cabinet is not less than 120Pa.
Face mask pressure is not less than 100Pa.
Aerosol generation flow rate: more than 0.2 mL/min.
Perform inhalation test for 3 monkeys.
Stability and evenness error of microbial aerosol is less than ±20%.
RB∕T 199-2015 Technical code for evaluating biosafety performanceof laboratory equipment
OECD TG 403 Acute Inhalation Toxicity (2009)
OECD TG 436 Acute Inhalation Toxicity; Acute Toxic Class Method (2009)
OECD TG 412 28d Sub-acute inhalation (2018)
OECD TG 413 90d Sub-chronic inhalation (2018)
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