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Multi-concentration Nose-only Exposure System for Rodents

Application

Drug Safety Evaluation;

Respiratory Disease Modeling and Drug Efficacy Evaluation;

Chemicals and Pesticide Safety Evaluation;

Hazard Assessment and Radioactive Substances Protection;

Inhalation Immunity and Environment Assessment;

Aerospace Medicine.

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Description

Features

Specification

Standards

Video

The instrument is used to conduct nose-only exposure tests for rodents, including inhalation exposure tests with multiple concentration doses of bioaerosols, chemical aerosols and smoke, etc. By generating 3 to 5 concentration doses simultaneously, it initially and internationally realizes generating aerosol at one time by single aerosol source, ensuring the consistency of aerosol sources of different test groups as well as reducing sample consumption. In addition, after setting different test doses on software, the system can automatically detect and adjust to target concentration.

Realize inhalation exposure test of homologous gases, vapors or mixtures with 3 to 5 concentration gradients.

Unique vortex mixing and dilution technology makes the concentration of inhalation test substances uniform and stable for all layers’ animals. The evenness and stability error of each exposure port's mass concentration during tests for gas is within ±8%, for liquid aerosol is within ±10%, while for dust aerosol is within ±20%, which conforms to technical requirements of OECD inhalation guidelines.

Negative pressure protection system can guarantee the safety of personnel.

Space-saving, low energy consumption and sample consumption.

Max. 5 times concentration gradient can be realized.

OECD Standards

OECD TG 403 Acute Inhalation Toxicity (2009);

OECD TG 436 Acute Inhalation Toxicity; Acute Toxic Class Method (2009);

OECD TG 412 28d Sub-acute inhalation (2018);

OECD TG 413 90d Sub-chronic inhalation (2018);

 

Pesticide Registration Standards

GB /T 15670.6 ~2017 Toxicological test methods for pesticides registration—Part 6: Acute inhalation toxicity test;

GB /T 15670.12 ~ 2017 Toxicological test methods for pesticides registration—Part 12: Short-term repeated dose 28-day inhalation toxicity study;

GB /T 15670.13 ~2017 Toxicological test methods for pesticides registration—Part 13: Subchronic toxicity study;

GB /T 15670.26 ~ 2017 Toxicological test methods for pesticides registration—Part 26: Chronic toxicity study;

 

Registration of New Chemical Substances by Ministry of Ecology and Environment

403 Acute Inhalation Toxicity(2013, 2nd edition);

436 Acute Inhalation Toxicity Test:Acute Toxic Class Method(2013, 2nd edition);

412 Sub-acute inhalation:28-days test(2013, 2nd edition);

 

413 Sub-chronic inhalation:90-days test(2013, 2nd edition);

 

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