The Multi-Concentration Cell Exposure System is an in vitro multi-channel exposure system for inhalable substances, developed based on ALI (Air-Liquid Interface) technology. A single experiment can accommodate cell exposure tests with 3 concentration groups and 1 control group, with at least 3 parallel cell exposure replicates for each concentration. The Multi-Concentration Cell Exposure System features advantages such as ensuring sample homogeneity across different concentration groups, high experimental efficiency, and low sample consumption.
1.Direct exposure to monolayer cultured cells or bacteria.
2.ALI- Air-Liquid interface exposure that exactly mimics the in vivo environment.
3.The aerosol is uniformly distributed within the exposure chamber and flows at a constant rate.
4.Ensure consistency of flow rate and concentration for the same concentration.
5.The biosafety cabinet provides a super clean laboratory environment, with all parts of the exposed module removable for sterilization.
6.Aerosol mass concentration detector could adjust and precisely control the concentration of flue gases or aerosol.
7.Flow control accuracy up to ±1.5%F.S.
8.With high efficiency, up to 9 exposure units in 3 concentrations can be conducted simultaneously.
9.Thermostatic water bath temperature control accuracy of ±0.3℃.
10.Industrial controller has touch screen, stable performance, small and delicate appearance.
11.User-friendly HMI and highly intelligent control software with easy operation.
12.Effectively reduce noise by adopting a silent air compressor.
13.The module was reasonably simplified, adopting mature modules to ensure the reliability of test accuracy.
ALI- Air-Liquid Interface Exposure.
Exposure flow rate of a single channel is 5-20ml.
Up to 3 concentrations and 1 control group test.
Aerosol concentration online monitoring.
Flow control accuracy ±1%F.S..
Compatible with quartz crystal microbalance.
Compatible with 6-channel and 12-channel transwell chambers.
Water bath temp control accuracy ±0.3℃.
Optional clean bench / safety cabinet to provide clean exposure environment.
OECD Guidelines
① OECD TG 403 Acute Inhalation Toxicity (2009);
② OECD TG 436 Acute Inhalation Toxicity; Acute Toxic Class Method (2009);
③ OECD TG 412 28d Sub-acute inhalation (2018);
④ OECD TG 413 90d Sub-chronic inhalation (2018);
Academy of Military Medical Sciences
China Institute for Radiation Protection
Institute of Materia Medica Chinese Academy of Medical Science
Guangxi University of Science and Technology
Jiangsu Provincial Center for Disease Control and Prevention
North China University of Science and Technology
China Tobacco Quality Supervision and Inspection Center
Shanxi Medical University
Xinxiang Medical University
Inner Mongolia Medical University
China Tobacco Guangdong Industrial Corporation Limited
Soochow University
China CDC
…
关注官方公众号