The system can be used to conduct inhalation exposure tests of rodents (rats, mice, guinea pigs, etc.) exposure to gas, vapor, liquid aerosols, solid aerosols, nanoparticle aerosols, etc.
The uniformity and stability deviation of animal respiratory tract for gas is within ±8%, for liquid aerosol is within ±10%, while for dust aerosol is within ±20%, which conforms to technical requirements of OECD guidelines.
Aerosol particle size distribution is MMAD1-3μm, GSD1.5-3.
The temp, humidity, oxygen and carbon dioxide concentration of whole body exposure chamber during test meet requirements of inhalation guidelines.
One cage for one rat inhalation exposure can perform 20-80 rats test simultaneously.
Real-time monitor temp, humidity, pressure difference, oxygen and carbon dioxide concentration of exposure chamber during tests. Parameters can be controlled according to requirements of laboratory, e.g., air inlet flow, dilution flow, sampling flow, exhaust flow, exposure time, remaining time, etc.
OECD Guidelines
① OECD TG 403 Acute Inhalation Toxicity (2009);
② OECD TG 436 Acute Inhalation Toxicity; Acute Toxic Class Method (2009);
③ OECD TG 412 28d Sub-acute inhalation (2018);
④ OECD TG 413 90d Sub-chronic inhalation (2018);
Pesticide Registration Standards
① GB /T 15670.6 ~2017 Toxicological test methods for pesticides registration—Part 6: Acute inhalation toxicity test;
② GB /T 15670.12 ~ 2017 Toxicological test methods for pesticides registration—Part 12: Short-term repeated dose 28-day inhalation toxicity study;
③ GB /T 15670.13 ~2017 Toxicological test methods for pesticides registration—Part 13: Subchronic toxicity study;
④ GB /T 15670.26 ~ 2017 Toxicological test methods for pesticides registration—Part 26: Chronic toxicity study;
Registration of New Chemical Substances by Ministry of Ecology and Environment
① 403 Acute Inhalation Toxicity(2013, 2nd edition);
② 436 Acute Inhalation Toxicity Test:Acute Toxic Class Method(2013, 2nd edition);
③ 412 Sub-acute inhalation:28-days test(2013, 2nd edition);
④ 413 Sub-chronic inhalation:90-days test(2013, 2nd edition);
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