The Canine Nose-only Exposure System can conduct acute, subacute, chronic and sub-chronic nose-only inhalation tests of canine exposure to gas, vapor, liquid aerosols, solid aerosols, nanoparticle aerosols, etc.
Adopt stainless steel double static pressure chamber structure, it can perform inhalation tests for 6-10 canines simultaneously.
The uniformity and stability deviation of each exposure port's mass concentration during tests for gas is within ±8%, for liquid aerosol is within ±10%, while for dust aerosol is within ±20%, which conforms to technical requirements of OECD guidelines.
Achieve dynamic monitoring of the test article mass concentration, in compliance with OECD TG 403 and OECD TG 436.
Enable real-time online detection of aerosol particle size distribution and manual particle size analysis (optional).
Waste gas can fully meet Safety Emission Standards after treatment.
The unique structural and air pressure control of exposure system ensures tight protection. Protection alarm is effective against abnormal temp, abnormal pressure difference and gas leakage.
Unique human machine interface (HMI) for intuitive and convenient operation. Powerful software and hardware supporting system; the software complies with GLP requirements.
OECD Guidelines
① OECD TG 403 Acute Inhalation Toxicity (2009);
② OECD TG 436 Acute Inhalation Toxicity; Acute Toxic Class Method (2009);
③ OECD TG 412 28d Sub-acute inhalation (2018);
④ OECD TG 413 90d Sub-chronic inhalation (2018);
Pesticide Registration Standards
① GB /T 15670.6 ~2017 Toxicological test methods for pesticides registration—Part 6: Acute inhalation toxicity test;
② GB /T 15670.12 ~ 2017 Toxicological test methods for pesticides registration—Part 12: Short-term repeated dose 28-day inhalation toxicity study;
③ GB /T 15670.13 ~2017 Toxicological test methods for pesticides registration—Part 13: Subchronic toxicity study;
④ GB /T 15670.26 ~ 2017 Toxicological test methods for pesticides registration—Part 26: Chronic toxicity study;
Registration of New Chemical Substances by Ministry of Ecology and Environment
① 403 Acute Inhalation Toxicity(2013, 2nd edition);
② 436 Acute Inhalation Toxicity Test:Acute Toxic Class Method(2013, 2nd edition);
③ 412 Sub-acute inhalation:28-days test(2013, 2nd edition);
④ 413 Sub-chronic inhalation:90-days test(2013, 2nd edition);
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